Viral Load Kinetics of SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study.
Identifieur interne : 000077 ( Main/Exploration ); précédent : 000076; suivant : 000078Viral Load Kinetics of SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study.
Auteurs : Seong Eun Kim [Corée du Sud] ; Ji Yeon Lee [Corée du Sud] ; Ahrang Lee [Corée du Sud] ; Soosung Kim [Corée du Sud] ; Kyung Hwa Park [Corée du Sud] ; Sook In Jung [Corée du Sud] ; Seung Ji Kang [Corée du Sud] ; Tae Hoon Oh [Corée du Sud] ; Uh Jin Kim [Corée du Sud] ; Seung Yeob Lee [Corée du Sud] ; Seung Jung Kee [Corée du Sud] ; Hee Chang Jang [Corée du Sud]Source :
- Journal of Korean medical science [ 1598-6357 ] ; 2020.
Descripteurs français
- KwdFr :
- ARN viral (métabolisme), Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (génétique), Betacoronavirus (isolement et purification), Charge virale (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Jeune adulte (MeSH), Mâle (MeSH), Pandémies (MeSH), Partie nasale du pharynx (virologie), Pneumopathie virale (diagnostic), Pneumopathie virale (virologie), Réaction de polymérisation en chaine en temps réel (MeSH), République de Corée (MeSH), Salive (virologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Études prospectives (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- génétique : Betacoronavirus.
- isolement et purification : Betacoronavirus.
- métabolisme : ARN viral.
- virologie : Infections à coronavirus, Partie nasale du pharynx, Pneumopathie virale, Salive.
- Adolescent, Adulte, Adulte d'âge moyen, Charge virale, Femelle, Humains, Jeune adulte, Mâle, Pandémies, Réaction de polymérisation en chaine en temps réel, République de Corée, Sujet âgé, Sujet âgé de 80 ans ou plus, Études prospectives.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Coronavirus Infections (diagnosis), Coronavirus Infections (virology), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Nasopharynx (virology), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (virology), Prospective Studies (MeSH), RNA, Viral (metabolism), Real-Time Polymerase Chain Reaction (MeSH), Republic of Korea (MeSH), Saliva (virology), Viral Load (MeSH), Young Adult (MeSH).
- MESH :
- chemical , metabolism : RNA, Viral.
- geographic : Republic of Korea.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Nasopharynx, Pneumonia, Viral, Saliva.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Pandemics, Prospective Studies, Real-Time Polymerase Chain Reaction, Viral Load, Young Adult.
Abstract
BACKGROUND
This study was performed to compare the viral load and kinetics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in saliva with those in standard nasopharyngeal/oropharyngeal (NP/OP) swabs.
METHODS
Fifteen patients with SARS-CoV-2 infection from four hospitals were prospectively enrolled and matched samples of nasopharyngeal/oropharyngeal swabs and saliva were collected at Day 1 of admission and every other day till consequently negative for two times. Real-time reverse transcription polymerase chain reaction (rRT-PCR) was performed to detect the envelope (E) and RNA-dependent RNA polymerase (RdRP) genes.
RESULTS
The cycle threshold values of saliva were comparable to those of NP/OP swabs overall (
CONCLUSION
Saliva sample itself is not appropriate for initial diagnosis of coronavirus disease 2019 (COVID-19) to replace NP/OP swabs, especially for the person who does not produce sputum. COVID-19 cannot be excluded when the test using saliva is negative, and it is necessary to retest using NP/OP swabs.
DOI: 10.3346/jkms.2020.35.e287
PubMed: 32776725
PubMed Central: PMC7415999
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Kee, Seung Jung" sort="Kee, Seung Jung" uniqKey="Kee S" first="Seung Jung" last="Kee">Seung Jung Kee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Jang, Hee Chang" sort="Jang, Hee Chang" uniqKey="Jang H" first="Hee Chang" last="Jang">Hee Chang Jang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam 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SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study.</title><author><name sortKey="Kim, Seong Eun" sort="Kim, Seong Eun" uniqKey="Kim S" first="Seong Eun" last="Kim">Seong Eun Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Ji Yeon" sort="Lee, Ji Yeon" uniqKey="Lee J" first="Ji Yeon" last="Lee">Ji Yeon Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Keimyung University Dongsan Hospital, Daegu, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Keimyung University Dongsan Hospital, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Ahrang" sort="Lee, Ahrang" uniqKey="Lee A" first="Ahrang" last="Lee">Ahrang Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Soosung" sort="Kim, Soosung" uniqKey="Kim S" first="Soosung" last="Kim">Soosung Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Park, Kyung Hwa" sort="Park, Kyung Hwa" uniqKey="Park K" first="Kyung Hwa" last="Park">Kyung Hwa Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Jung, Sook In" sort="Jung, Sook In" uniqKey="Jung S" first="Sook In" last="Jung">Sook In Jung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Kang, Seung Ji" sort="Kang, Seung Ji" uniqKey="Kang S" first="Seung Ji" last="Kang">Seung Ji Kang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Bitgoeul Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Bitgoeul Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Oh, Tae Hoon" sort="Oh, Tae Hoon" uniqKey="Oh T" first="Tae Hoon" last="Oh">Tae Hoon Oh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Hwasun Hospital, Hwasun, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Hwasun Hospital, Hwasun</wicri:regionArea><wicri:noRegion>Hwasun</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Uh Jin" sort="Kim, Uh Jin" uniqKey="Kim U" first="Uh Jin" last="Kim">Uh Jin Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Hwasun Hospital, Hwasun, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Hwasun Hospital, Hwasun</wicri:regionArea><wicri:noRegion>Hwasun</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Seung Yeob" sort="Lee, Seung Yeob" uniqKey="Lee S" first="Seung Yeob" last="Lee">Seung Yeob Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Kee, Seung Jung" sort="Kee, Seung Jung" uniqKey="Kee S" first="Seung Jung" last="Kee">Seung Jung Kee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author><author><name sortKey="Jang, Hee Chang" sort="Jang, Hee Chang" uniqKey="Jang H" first="Hee Chang" last="Jang">Hee Chang Jang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea. haroc153@naver.com.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju</wicri:regionArea><wicri:noRegion>Gwangju</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Korean medical science</title><idno type="eISSN">1598-6357</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (isolation & purification)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (virology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Nasopharynx (virology)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (virology)</term><term>Prospective Studies (MeSH)</term><term>RNA, Viral (metabolism)</term><term>Real-Time Polymerase Chain Reaction (MeSH)</term><term>Republic of Korea (MeSH)</term><term>Saliva (virology)</term><term>Viral Load (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (métabolisme)</term><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (génétique)</term><term>Betacoronavirus (isolement et purification)</term><term>Charge virale (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (virologie)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Partie nasale du pharynx (virologie)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (virologie)</term><term>Réaction de polymérisation en chaine en temps réel (MeSH)</term><term>République de Corée (MeSH)</term><term>Salive (virologie)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Republic of Korea</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Partie nasale du pharynx</term><term>Pneumopathie virale</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Nasopharynx</term><term>Pneumonia, Viral</term><term>Saliva</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prospective Studies</term><term>Real-Time Polymerase Chain Reaction</term><term>Viral Load</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Réaction de polymérisation en chaine en temps réel</term><term>République de Corée</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>This study was performed to compare the viral load and kinetics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in saliva with those in standard nasopharyngeal/oropharyngeal (NP/OP) swabs.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Fifteen patients with SARS-CoV-2 infection from four hospitals were prospectively enrolled and matched samples of nasopharyngeal/oropharyngeal swabs and saliva were collected at Day 1 of admission and every other day till consequently negative for two times. Real-time reverse transcription polymerase chain reaction (rRT-PCR) was performed to detect the envelope (E) and RNA-dependent RNA polymerase (RdRP) genes.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The cycle threshold values of saliva were comparable to those of NP/OP swabs overall (</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Saliva sample itself is not appropriate for initial diagnosis of coronavirus disease 2019 (COVID-19) to replace NP/OP swabs, especially for the person who does not produce sputum. COVID-19 cannot be excluded when the test using saliva is negative, and it is necessary to retest using NP/OP swabs.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32776725</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1598-6357</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>31</Issue><PubDate><Year>2020</Year><Month>Aug</Month><Day>10</Day></PubDate></JournalIssue><Title>Journal of Korean medical science</Title><ISOAbbreviation>J Korean Med Sci</ISOAbbreviation></Journal><ArticleTitle>Viral Load Kinetics of SARS-CoV-2 Infection in Saliva in Korean Patients: a Prospective Multi-center Comparative Study.</ArticleTitle><Pagination><MedlinePgn>e287</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2020.35.e287</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This study was performed to compare the viral load and kinetics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in saliva with those in standard nasopharyngeal/oropharyngeal (NP/OP) swabs.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fifteen patients with SARS-CoV-2 infection from four hospitals were prospectively enrolled and matched samples of nasopharyngeal/oropharyngeal swabs and saliva were collected at Day 1 of admission and every other day till consequently negative for two times. Real-time reverse transcription polymerase chain reaction (rRT-PCR) was performed to detect the envelope (E) and RNA-dependent RNA polymerase (RdRP) genes.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The cycle threshold values of saliva were comparable to those of NP/OP swabs overall (<i>P</i> = 0.720, Mann-Whitney U test). However, the overall sensitivity of rRT-PCR using saliva was 64% (34/53), which is lower than the 77% (41/53) using NP/OP swabs. The sensitivity of rRT-PCR using saliva was especially lower in early stage of symptom onset (1-5 days; 8/15; 53%) and in patients who did not have sputum (12/22; 55%).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Saliva sample itself is not appropriate for initial diagnosis of coronavirus disease 2019 (COVID-19) to replace NP/OP swabs, especially for the person who does not produce sputum. COVID-19 cannot be excluded when the test using saliva is negative, and it is necessary to retest using NP/OP swabs.</AbstractText><CopyrightInformation>© 2020 The Korean Academy of Medical Sciences.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Kim</LastName><ForeName>Seong Eun</ForeName><Initials>SE</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-0162-6155</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Lee</LastName><ForeName>Ji Yeon</ForeName><Initials>JY</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2788-1392</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Keimyung University Dongsan Hospital, Daegu, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ahrang</ForeName><Initials>A</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-6013-9843</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Soosung</ForeName><Initials>S</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-7797-6277</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Kyung Hwa</ForeName><Initials>KH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2836-6963</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jung</LastName><ForeName>Sook In</ForeName><Initials>SI</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1577-678X</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Seung Ji</ForeName><Initials>SJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3298-0520</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Bitgoeul Hospital, Gwangju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>Tae Hoon</ForeName><Initials>TH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-0788-5780</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Hwasun Hospital, Hwasun, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Uh Jin</ForeName><Initials>UJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8463-6297</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Hwasun Hospital, Hwasun, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Seung Yeob</ForeName><Initials>SY</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2851-1112</Identifier><AffiliationInfo><Affiliation>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kee</LastName><ForeName>Seung Jung</ForeName><Initials>SJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-9708-5837</Identifier><AffiliationInfo><Affiliation>Department of Laboratory Medicine, Chonnam National University Hospital, Gwangju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jang</LastName><ForeName>Hee Chang</ForeName><Initials>HC</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3407-8493</Identifier><AffiliationInfo><Affiliation>Department of Infectious Diseases, Chonnam National University Hospital, Gwangju, Korea. haroc153@naver.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CNU 2020-1967</GrantID><Acronym>CNU</Acronym><Agency>Chonnam National University</Agency><Country>Korea</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>J Korean Med Sci</MedlineTA><NlmUniqueID>8703518</NlmUniqueID><ISSNLinking>1011-8934</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056910" MajorTopicYN="N" Type="Geographic">Republic of Korea</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Nasopharyngeal Swab</Keyword><Keyword MajorTopicYN="N">Oropharyngeal Swab</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2 PCR</Keyword><Keyword MajorTopicYN="N">Saliva</Keyword></KeywordList><CoiStatement>The authors have no potential conflicts of interest to disclose.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>03</Day></PubMedPubDate><PubMedPubDate 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Kang</name><name sortKey="Kee, Seung Jung" sort="Kee, Seung Jung" uniqKey="Kee S" first="Seung Jung" last="Kee">Seung Jung Kee</name><name sortKey="Kim, Soosung" sort="Kim, Soosung" uniqKey="Kim S" first="Soosung" last="Kim">Soosung Kim</name><name sortKey="Kim, Uh Jin" sort="Kim, Uh Jin" uniqKey="Kim U" first="Uh Jin" last="Kim">Uh Jin Kim</name><name sortKey="Lee, Ahrang" sort="Lee, Ahrang" uniqKey="Lee A" first="Ahrang" last="Lee">Ahrang Lee</name><name sortKey="Lee, Ji Yeon" sort="Lee, Ji Yeon" uniqKey="Lee J" first="Ji Yeon" last="Lee">Ji Yeon Lee</name><name sortKey="Lee, Seung Yeob" sort="Lee, Seung Yeob" uniqKey="Lee S" first="Seung Yeob" last="Lee">Seung Yeob Lee</name><name sortKey="Oh, Tae Hoon" sort="Oh, Tae Hoon" uniqKey="Oh T" first="Tae Hoon" last="Oh">Tae Hoon Oh</name><name sortKey="Park, Kyung Hwa" sort="Park, Kyung Hwa" uniqKey="Park K" first="Kyung Hwa" last="Park">Kyung Hwa Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix 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